Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy

Zhang, Y; Zhang, NJ; Zou, YM; Song, CY; Cao, KX; Wu, BQ; You, SL; Lu, SE; Wang, D; Xu, JQ; Huang, XY; Zhang, PY; Fan, ZH; Liu, JW; Cheng, ZY; Zhang, Z; Kong, CZ; Cao, L; Sun, YX

Sun, YX (通讯作者),China Med Univ, Hosp 1, Dept Cardiol, 115 Nanjing N St, Shenyang 110001, Liaoning, Peoples R China.;Cao, L (通讯作者),China Med Univ, Coll Basic Med Sci, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China.;Cao, L (通讯作者),China Med Univ, Key Lab Med Cell Biol, Minist Educ, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China.;Cao, L (通讯作者),China Med Univ, Liaoning Prov Collaborat Innovat Ctr Aging Related, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China.;Zhang, NJ (通讯作者),China Med Univ, Hosp 1, Dept Cardiol, 155 Nanjing N St, Shenyang 110001, Liaoning, Peoples R China.;Zhang, NJ (通讯作者),China Med Univ, Inst Hlth Sci, Key Lab Reprod & Genet Med, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China.;Zhang, NJ (通讯作者),China Med Univ, Key Lab Reprod & Genet Med, Natl Hlth Commiss, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China.

CIRCULATION RESEARCH, 2023; 132 (5): 601

Abstract

Background:Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyt......

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