Crowders Steal Dihydrofolate Reductase Ligands through Quinary Interactions

Duff, MR; Desai, N; Craig, MA; Agarwal, PK; Howell, EE

Howell, EE (reprint author), Univ Tennessee, Dept Biochem, Knoxville, TN 37996 USA.

BIOCHEMISTRY, 2019; 58 (9): 1198

Abstract

Dihydrofolate reductase (DHFR) reduces dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor. Due to its role in one carbon metabolism, ch......

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