ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology

Cao, YL; Xu, HC; Zhu, YB; Shi, MJ; Wei, LX; Zhang, J; Cheng, S; Shi, YQ; Tong, HY; Kang, LJ; Lu, L; Luo, HY; Yang, X; Bai, XF; Wang, RR; Ma, YY; Wang, Y; Wang, ZF; Zhong, K; Zhao, BQ; Fan, WY

Zhao, BQ; Fan, WY (reprint author), Fudan Univ, State Key Lab Med Neurobiol, Jingan Dist Ctr Hosp Shanghai, Dept Translat Neurosci, Shanghai, Peoples R China.; Zhao, BQ; Fan, WY (reprint author), Fudan Univ, MOE Frontiers Ctr Brain Sci, Inst Brain Sci, Sh

PLOS BIOLOGY, 2019; 17 (6):

Abstract

Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-beta (A beta) brain accumulation and drive Alzheimer disease (......

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