Deuterium-Enabled Chiral Switching (DECS) Yields Chirally Pure Drugs from Chemically Interconverting Racemates

DeWitt, S; Czarnik, AW; Jacques, V

Jacques, V (corresponding author), DeuteRx LLC, Andover, MA 01810 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (10): 1789

Abstract

Separation of the preferred enantiomer from racemic mixtures, i.e. "chiral switching," often improves efficacy and reduces toxicity. However, this str......

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