A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells

Usta, D; Sigaud, R; Buhl, JL; Selt, F; Marquardt, V; Pauck, D; Jansen, J; Pusch, S; Ecker, J; Hielscher, T; Vollmer, J; Sommerkamp, AC; Rubner, T; Hargrave, D; van Tilburg, CM; Pfister, SM; Jones, DTW; Remke, M; Brummer, T; Witt, O; Milde, T

Milde, T (corresponding author), Hopp Childrens Canc Ctr Heidelberg KiTZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

MOLECULAR CANCER THERAPEUTICS, 2020; 19 (8): 1736

Abstract

Pilocytic astrocytomas as well as other pediatric low-grade gliomas (pLGG) exhibit genetic events leading to aberrant activation of the MAPK pathway. ......

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