Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Kim, H; Xu, HN; George, E; Hallberg, D; Kumar, S; Jagannathan, V; Medvedev, S; Kinose, Y; Devins, K; Verma, P; Ly, K; Wang, YF; Greenberg, RA; Schwartz, L; Johnson, N; Scharpf, RB; Mills, GB; Zhang, RG; Velculescu, VE; Brown, EJ; Simpkins, F

Simpkins, F (corresponding author), Univ Penn, Penn Ovarian Canc Res Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Philadelphia, PA 19104 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP inhibitors (PARPi). We show that acquisition of PARPi-resistanc......

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