Diabetogenic agent alloxan is a proteasome inhibitor

Zhou, WJ; Wei, LL; Xiao, T; Lai, CY; Peng, M; Xu, LL; Luo, XW; Deng, SP; Zhang, FX

Zhang, FX (reprint author), Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Sch Med, Chengdu 610072, SC, Peoples R China.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017; 488 (2): 400

Abstract

Alloxan has been used as a diabetogenic agent to induce diabetes. It selectively induces pancreatic beta-cell death. The specific toxicity, however, i......

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