Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

McCray, BA; Diehl, E; Sullivan, JM; Aisenberg, WH; Zaccor, NW; Lau, AR; Rich, DJ; Goretzki, B; Hellmich, UA; Lloyd, TE; Sumner, CJ

McCray, BA; Sumner, CJ (corresponding author), Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.; Sumner, CJ (corresponding author), Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21218 USA.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant m......

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