Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery

Sanchez, AJD; Zhao, K; Huayamares, SG; Hatit, MZC; Lokugamage, MP; Loughrey, D; Dobrowolski, C; Wang, SS; Kim, H; Paunovska, K; Kuzminich, Y; Dahlman, JE

Dahlman, JE (通讯作者),Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA.

JOURNAL OF CONTROLLED RELEASE, 2023; 353 (): 270

Abstract

Lipid nanoparticles (LNPs) have delivered siRNA and mRNA drugs in humans, underscoring the potential impact of improving the therapeutic window of nex......

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