GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity

Cox, MJ; Roman, CM; Tapper, EE; Siegler, EL; Chappell, D; Durrant, C; Ahmed, O; Sinha, S; Mwangi, R; Scott, NS; Hefazi, M; Schick, KJ; Horvei, P; Ruff, MW; Can, I; Adada, M; Bezerra, E; Fonkoua, LAK; Parikh, SA; Kay, NE; Sakemura, R; Kenderian, SS

Kenderian, SS (通讯作者)，Mayo Clin, T Cell Engn, Rochester, MN 55902 USA.;Kenderian, SS (通讯作者)，Mayo Clin, Div Hematol, Rochester, MN 55902 USA.;Kenderian, SS (通讯作者)，Mayo Clin, Dept Mol Med, Rochester, MN 55902 USA.;Kenderian, SS (通讯作者)，Mayo Clin, Grad Sch Biomed Sci, Rochester, MN 55902 USA.;Kenderian, SS (通讯作者)，Mayo Clin, Dept Immunol, Rochester, MN 55902 USA.

LEUKEMIA, 2022; 36 (6): 1635

Abstract

Inhibitory myeloid cells and their cytokines play critical roles in limiting chimeric antigen receptor T (CART) cell therapy by contributing to the de......

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