Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state

Li, S; Sun, J; Liu, SX; Zhou, FB; Gross, ML; Li, WK

Li, WK (通讯作者),Washington Univ St Louis, Sch Med, Dept Biochem Biophys, 660 S Euclid Ave, St Louis, MO 63110 USA.

BLOOD ADVANCES, 2023; 7 (10): 2271

Abstract

Missense vitamin K epoxide reductase (VKOR) mutations in patients cause resistance to warfarin treatment but not abnormal bleeding due to defective VK......

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