Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin

Ferguson, JA; Sun, X; Dyson, HJ; Wright, PE

Wright, PE (corresponding author), Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.; Wright, PE (corresponding author), Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.

BIOCHEMISTRY, 2021; 60 (10): 756

Abstract

Misfolding and aggregation of transthyretin (TTR) are linked to amyloid disease. Amyloidosis occurs when the TTR homotetramer dissociates into aggrega......

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