Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection

Jiang, J; Chen, JQ; Liao, C; Duan, YT; Wang, YJ; Shang, K; Huang, YJ; Tang, YM; Gao, XF; Gu, Y; Sun, J

Sun, J (通讯作者),Zhejiang Univ, Affiliated Hosp 1, Bone Marrow Transplantat Ctr, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.;Sun, J (通讯作者),Zhejiang Univ, Dept Cell Biol, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.;Gu, Y; Sun, J (通讯作者),Zhejiang Univ, Liangzhu Lab, Med Ctr, 1369 West Wenyi Rd, Hangzhou 311121, Peoples R China.;Sun, J (通讯作者),Zhejiang Univ, Inst Hematol, Hangzhou 310058, Zhejiang, Peoples R China.;Sun, J (通讯作者),Zhejiang Engn Lab Stem Cell & Immunotherapy, Hangzhou 310058, Zhejiang, Peoples R China.;Gu, Y (通讯作者),Zhejiang Univ, Affiliated Hosp 2, Sch Med, Canc Inst,Key Lab Canc Prevent & Intervent,China N, Hangzhou 310009, Zhejiang, Peoples R China.;Gu, Y (通讯作者),Zhejiang Univ, Inst Genet, Hangzhou 310058, Peoples R China.;Gu, Y (通讯作者),Zhejiang Univ, Sch Med, Dept Genet, Hangzhou 310058, Peoples R China.;Gu, Y (通讯作者),Zhejiang Prov Key Lab Genet & Dev Disorder, Hangzhou 310058, Zhejiang, Peoples R China.

LEUKEMIA, 2023; 37 (8): 1660

Abstract

CAR-T therapies to treat T-cell malignancies face unique hurdles. Normal and malignant T cells usually express the same target for CAR, leading to fra......

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