Characterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases

Li, S; Liu, SX; Yang, YH; Li, WK

Li, WK (corresponding author), Washington Univ, Sch Med, Dept Biochem & Mol Biophys, 660 S Euclid Ave, St Louis, MO 63110 USA.

JOURNAL OF MOLECULAR BIOLOGY, 2020; 432 (18): 5197

Abstract

Intramembrane enzymes are often difficult for biochemical characterization. Human vitamin K epoxide reductase (VKOR) is the target of warfarin. Howeve......

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