Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

Rojas-Restrepo, J; Sindram, E; Zenke, S; Haberstroh, H; Mitsuiki, N; Gabrysch, A; Huebscher, K; Posadas-Cantera, S; Krausz, M; Kobbe, R; Rohr, JC; Grimbacher, B; Gámez-Díaz, L

Grimbacher, B; Gámez-Díaz, L (通讯作者),Univ Freiburg, Med Ctr, Fac Med, Inst Immunodeficiency, Freiburg, Germany.;Grimbacher, B; Gámez-Díaz, L (通讯作者),Univ Freiburg, Fac Med, Med Ctr, Ctr Chron Immunodeficiency, Freiburg, Germany.;Grimbacher, B (通讯作者),Univ Med Ctr Freiburg, Dept Rheumatol & Clin Immunol, Freiburg, Germany.;Grimbacher, B (通讯作者),DZIF, German Ctr Infect Res, Satellite Ctr Freiburg, Freiburg, Germany.;Grimbacher, B (通讯作者),Univ Freiburg, Ctr Integrat Biol Signaling Studies, CIBSS, Freiburg, Germany.;Grimbacher, B (通讯作者),RESIST, Satellite Ctr Freiburg, Cluster Excellence Hanover Med Sch 2155, Freiburg, Germany.

JOURNAL OF CLINICAL IMMUNOLOGY, 2023; 43 (8): 2076

Abstract

Variants of uncertain significance (VUS) in CTLA4 are frequently identified in patients with antibody deficiency or immune dysregulation syndromes inc......

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