Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Zhao, L; Wang, SM; Xu, M; He, Y; Zhang, XW; Xiong, Y; Sun, H; Ding, HB; Geng, WQ; Shang, H; Liang, GX

Liang, GX (corresponding author), China Med Univ, Affiliated Hosp 1, Minist Hlth, Dept Lab Med,Key Lab AIDS Immunol, Shenyang, Peoples R China.; Liang, GX (corresponding author), China Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Lab Med, Shenyang, Peoples R China.; Liang, GX (corresponding author), China Med Univ, Affiliated Hosp 1, Res Inst Canc Therapy, Shenyang, Peoples R China.; Liang, GX (corresponding author), Chinese Acad Med Sci, Key Lab AIDS Immunol, Shenyang, Peoples R China.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the inhibitory effects of the host cell restriction factors APOBEC3......

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