Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors

Weber, C; Sipos, M; Paczal, A; Balint, B; Kun, V; Foloppe, N; Dokurno, P; Massey, AJ; Walmsley, DL; Hubbard, RE; Murray, J; Benwell, K; Edmonds, T; Demarles, D; Bruno, A; Burbridge, M; Cruzalegui, F; Kotschy, A

Kotschy, A (corresponding author), Servier Res Inst Med Chem, H-1031 Budapest, Hungary.

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (10): 6745

Abstract

The kinase DYRK1A is an attractive target for drug discovery programs due to its implication in multiple diseases. Through a fragment screen, we ident......

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