C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression

Sun, Y; Eshov, A; Zhou, J; Isiktas, AU; Guo, JJU

Guo, JJU (corresponding author), Yale Univ, Sch Med, Dept Neurosci, 333 Cedar St, New Haven, CT 06520 USA.; Guo, JJU (corresponding author), Yale Univ, Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, 333 Cedar St, New Haven, CT 06520 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Expansion of an intronic (GGGGCC)(n) repeat region within the C9orf72 gene is a main cause of familial amyotrophic lateral sclerosis and frontotempora......

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