Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

El-Mesallamy, HO; El Magdoub, HM; Chapman, JM; Hamdy, NM; Schaalan, MF; Hammad, LN; Berger, SH

El-Mesallamy, HO (reprint author), Ain Shams Univ, Dept Biochem, Fac Pharm, Cairo, Egypt.

PLOS ONE, 2018; 13 (3):

Abstract

Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory......

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