Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial

Hong, DS; Van Tine, BA; Biswas, S; McAlpine, C; Johnson, ML; Olszanski, AJ; Clarke, JM; Araujo, D; Blumenschein, GR; Kebriaei, P; Lin, Q; Tipping, AJ; Sanderson, JP; Wang, RX; Trivedi, T; Annareddy, T; Bai, JE; Rafail, S; Sun, AMY; Fernandes, L; Navenot, JM; Bushman, FD; Everett, JK; Karadeniz, D; Broad, R; Isabelle, M; Naidoo, R; Bath, N; Betts, G; Wolchinsky, Z; Batrakou, DG; Van Winkle, E; Elefant, E; Ghobadi, A; Cashen, A; Grand'Maison, A; McCarthy, P; Fracasso, PM; Norry, E; Williams, D; Druta, M; Liebner, DA; Odunsi, K; Butler, MO

Hong, DS (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Div Canc Med, Houston, TX 77030 USA.

NATURE MEDICINE, 2023; 29 (1): 104

Abstract

Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte anti......

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