Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Al Temimi, AHK; White, PB; Mulders, MJM; van der Linden, NGA; Blaauw, RH; Wegert, A; Rutjes, FPJT; Mecinovic, J

Rutjes, FPJT; Mecinovic, J (corresponding author), Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands.; Wegert, A (corresponding author), Mercachem BV, Kerkenbos 1013, NL-6546 BB Nijmegen, Netherlands.; Mecinovic, J (corresponding author), Univ Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.

CHEMICAL COMMUNICATIONS, 2020; 56 (20): 3039

Abstract

We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geome......

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