Effects of Thermally Induced Configuration Changes on rAAV Genome's Enzymatic Accessibility

Xu, YX; Guo, P; Zhang, JP; Chrzanowski, M; Chew, H; Firrman, JA; Sang, NL; Diao, Y; Xiao, WD

Xiao, WD (corresponding author), Indiana Univ, Herman B Wells Ctr Pediat Res, 1044 W Walnut St,R4-121, Indianapolis, IN 46202 USA.; Diao, Y (corresponding author), Huaqiao Univ, Ctr Mol Med, 269 Chenghua North St Fengze, Quanzhou 362021, Fujian, Peoples R China.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020; 18 (): 328

Abstract

Physical titers for recombinant adeno-associated viral (rAAV) vectors are measured by quantifying viral genomes. It is generally perceived that AAV vi......

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