In vitro ribosome synthesis and evolution through ribosome display

Hammerling, MJ; Fritz, BR; Yoesep, DJ; Kim, DS; Carlson, ED; Jewett, MC

Jewett, MC (corresponding author), Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Jewett, MC (corresponding author), Northwestern Univ, Ctr Synthet Biol, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Jewett, MC (corresponding author), Northwestern Univ, Simpson Querrey Inst, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Jewett, MC (corresponding author), Northwestern Univ, Chem Life Proc Inst, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Jewett, MC (corresponding author), Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, 2145 Sheridan Rd, Evanston, IL 60208 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Directed evolution of the ribosome for expanded substrate incorporation and novel functions is challenging because the requirement of cell viability l......

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