Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Nussinov, R; Zhang, MZ; Maloney, R; Liu, YL; Tsai, CJ; Jang, H

Nussinov, R (通讯作者),NCI, Computat Struct Biol Sect, Frederick Natl Lab Canc Res, Lab Canc Immunometab, Frederick, MD 21702 USA.

JOURNAL OF MOLECULAR BIOLOGY, 2022; 434 (17):

Abstract

Here, we discuss the principles of allosteric activating mutations, propagation downstream of the signals that they prompt, and allosteric drugs, with......

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