Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins

Du, J; Huang, ZY; Li, YC; Ren, XY; Zhou, CT; Liu, RL; Zhang, P; Lei, GJ; Lyu, J; Li, JH; Tan, GQ

Li, JH; Tan, GQ (通讯作者)，Wenzhou Med Univ, Coll Lab Med & Life Sci, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet,Minist Educ, Wenzhou 325035, Zhejiang, Peoples R China.;Lyu, J; Tan, GQ (通讯作者)，Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Lab Med Ctr,Dept Clin Lab, Hangzhou 310014, Zhejiang, Peoples R China.

FREE RADICAL BIOLOGY AND MEDICINE, 2023; 204 (): 359

Abstract

Copper is an essential mineral nutrient that provides the cofactors for some key enzymes. However, excess copper is paradoxically cytotoxic. Wilson's ......

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