Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

Wong, VKW; Qiu, CL; Xu, SW; Law, BYK; Zeng, W; Wang, H; Michelangeli, F; Dias, IRDR; Qu, YQ; Chan, TW; Han, Y; Zhang, N; Mok, SWF; Chen, X; Yu, L; Pan, HD; Hamdoun, S; Efferth, T; Yu, WJ; Zhang, W; Li, Z; Xie, YS; Luo, RQ; Jiang, Q; Liu, L

Liu, L (reprint author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China.

BRITISH JOURNAL OF PHARMACOLOGY, 2019; 176 (16): 2922

Abstract

Background and Purpose Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca2+ mobilization in......

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