Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-Raf(V600E) and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines

Lee, CI; Liao, CB; Chen, CS; Cheng, FY; Chung, YH; Wang, YC; Ciou, SY; Hsueh, WY; Lo, TH; Huang, GR; Huang, HY; Tsai, CS; Lu, YJ; Chuang, SH; Huang, JJ

Huang, JJ (corresponding author), Natl Chiayi Univ, Dept Appl Chem, 300 Syuefu Rd, Chiayi 60004, Taiwan.

BIOORGANIC CHEMISTRY, 2021; 109 ():

Abstract

This paper presents the design and synthesis of 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines of scaffold 9 as selective B-Raf/B-RafV600E......

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