Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Fazakerley, DJ; Minard, AY; Krycer, JR; Thomas, KC; Stockli, J; Harney, DJ; Burchfield, JG; Maghzal, GJ; Caldwell, ST; Hartley, RC; Stocker, R; Murphy, MP; James, DE

James, DE (reprint author), Univ Sydney, Sch Life & Environm Sci, Charles Perkins Ctr, Camperdown, NSW 2006, Australia.; James, DE (reprint author), Univ Sydney, Sydney Med Sch, Charles Perkins Ctr, Camperdown, NSW 2006, Australia.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018; 293 (19): 7315

Abstract

Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual r......

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