Proteolysis-targeting chimeras (PROTACs) in cancer therapy

Li, XY; Pu, WC; Zheng, QQ; Ai, M; Chen, S; Peng, Y

Peng, Y (通讯作者)，Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Frontiers Sci Ctr Dis Related Mol Network,Lab Mol, Chengdu 610064, Peoples R China.;Chen, S (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Dept Orthodont, State Key Lab Oral Dis,Natl Clin Res Ctr Oral Dis, Chengdu 610064, Peoples R China.

MOLECULAR CANCER, 2022; 21 (1):

Abstract

Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalentl......

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