Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes

Steffes, V; Macdonald, S; Crowe, J; Murali, M; Ewert, KK; Li, YL; Safinya, CR

Safinya, CR (通讯作者)，Univ Calif Santa Barbara, Mat Dept, Santa Barbara, CA 93106 USA.;Safinya, CR (通讯作者)，Univ Calif Santa Barbara, Phys Dept, Santa Barbara, CA 93106 USA.;Safinya, CR (通讯作者)，Univ Calif Santa Barbara, Mol Cellular & Dev Biol Dept, Santa Barbara, CA 93106 USA.

EUROPEAN PHYSICAL JOURNAL E, 2023; 46 (12):

Abstract

Paclitaxel (PTX) is a hydrophobic small-molecule cancer drug that loads into the membrane (tail) region of lipid carriers such as liposomes and micell......

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