ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

Lian, H; Wei, J; Zang, R; Ye, W; Yang, Q; Zhang, XN; Chen, YD; Fu, YZ; Hu, MM; Lei, CQ; Luo, WW; Li, S; Shu, HB

Li, S; Shu, HB (reprint author), Wuhan Univ, Med Res Inst, Sch Med, Wuhan 430071, Hubei, Peoples R China.; Shu, HB (reprint author), Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China.

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activate......

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