RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression

Liu, PF; de la Vega, MR; Sammani, S; Mascarenhas, JB; Kerins, M; Dodson, M; Sun, XG; Wang, T; Ooi, A; Garcia, JGN; Zhang, DD

Zhang, DD (reprint author), Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA.; Garcia, JGN (reprint author), Univ Arizona, Dept Med, Univ Arizona Hlth Sci, Tucson, AZ 85721 USA.; Zhang, DD (reprint author), Univ Arizona, Canc Ctr,

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (44): E10352

Abstract

NRF2 regulates cellular redox homeostasis, metabolic balance, and proteostasis by forming a dimer with small musculoaponeurotic fibrosarcoma proteins ......

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