Non-redundant activity of GSK-3 alpha and GSK-3 beta in T cell-mediated tumor rejection

Steele, L; Mannion, AJ; Shaw, G; Maclennan, KA; Cook, GP; Rudd, CE; Taylor, A

Taylor, A (corresponding author), Univ Leeds, Sch Med, Leeds Inst Med Res, St Jamess Univ Hosp, Wellcome Trust Brenner Bldg, Leeds LS9 7TF, W Yorkshire, England.

ISCIENCE, 2021; 24 (6):

Abstract

Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is eff......

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