Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling

Minnella, AM; Zhao, JX; Jiang, XN; Jakobsen, E; Lu, FX; Wu, L; El-Benna, J; Gray, JA; Swanson, RA

Swanson, RA (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94122 USA.; Swanson, RA (reprint author), San Francisco VA Med Ctr, San Francisco, CA 94121 USA.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

NMDA-type glutamate receptors (NMDAR) trigger superoxide production by neuronal NADPH oxidase-2 (NOX2), which if sustained leads to cell death. This p......

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