Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth

Chiu, M; Taurino, G; Bianchi, MG; Ottaviani, L; Andreoli, R; Ciociola, T; Lagrasta, CAM; Tardito, S; Bussolati, O

Bussolati, O (reprint author), Univ Parma, Dept Med & Surg, Lab Gen Pathol, Via Volturno 39, I-43125 Parma, Italy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018; 19 (4):

Abstract

In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, le......

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