Discovery of Covalent MKK4/7 Dual Inhibitor

Jiang, J; Jiang, BS; He, ZX; Ficarro, SB; Che, JW; Marto, JA; Gao, Y; Zhang, TH; Gray, NS

Zhang, TH; Gray, NS (corresponding author), Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.; Zhang, TH; Gray, NS (corresponding author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02215 USA.

CELL CHEMICAL BIOLOGY, 2020; 27 (12): 1553

Abstract

MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and ag......

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