Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1(D173A) mice

Wang, SZ; Lee, K; Gray, S; Zhang, YW; Tang, C; Morrish, RB; Tosti, E; van Oers, J; Amin, MR; Cohen, PE; MacCarthy, T; Roa, S; Scharff, MD; Edelmann, W; Chahwan, R

Scharff, MD; Edelmann, W (通讯作者)，Albert Einstein Coll Med, Dept Cell Biol, 1300 Morris Pk Ave, New York, NY 10461 USA.;Roa, S (通讯作者)，Univ Navarra, Dept Biochem & Genet, Pamplona 31008, Spain.;Roa, S (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Roa, S (通讯作者)，Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.;Chahwan, R (通讯作者)，Univ Zurich, Inst Expt Immunol, CH-8057 Zurich, Switzerland.

NUCLEIC ACIDS RESEARCH, 2022; 50 (14): 8093

Abstract

DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary co......

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