Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches

Hoffer, L; Muller, C; Roche, P; Morelli, X

Roche, P; Morelli, X (reprint author), Aix Marseille Univ, CNRS, INSERM, Inst Paoli Calmettes,CRCM, Marseille, France.; Morelli, X (reprint author), Inst Paoli Calmettes, IPC Drug Discovery, Marseille, France.

MOLECULAR INFORMATICS, 2018; 37 (9-10):

Abstract

For several decades, hit identification for drug discovery has been facilitated by developments in both fragment-based and high-throughput screening t......

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