Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling

Shen, P; Reineke, LC; Knutsen, E; Chen, M; Pichler, M; Ling, H; Calin, GA

Ling, H; Calin, GA (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.

MOLECULAR ONCOLOGY, 2018; 12 (11): 1856

Abstract

The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the det......

Full Text Link