CBF beta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

Pulikkan, JA; Hegde, M; Ahmad, HM; Belaghzal, H; Illendula, A; Yu, J; O'Hagan, K; Ou, JH; Muller-Tidow, C; Wolfe, SA; Zhu, LJ; Dekker, J; Bushweller, JH; Castilla, LH

Castilla, LH (reprint author), Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA.

CELL, 2018; 174 (1): 172

Abstract

The fusion oncoprotein CBF beta-SMMHC, expressed in leukemia cases with chromosome 16 inversion, drives leukemia development and maintenance by alteri......

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