Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation

Wu, CS; Rakhshandehroo, T; Wettersten, HI; Campos, A; von Schalscha, T; Jain, S; Yu, ZQ; Tan, JL; Mose, E; Childers, BG; Lowy, AM; Weis, SM; Cheresh, DA

Cheresh, DA (通讯作者),Univ Calif San Diego, Moores Canc Ctr, Dept Pathol, La Jolla, CA 92093 USA.;Cheresh, DA (通讯作者),Univ Calif San Diego, Sanford Consortium Regenerat Med, La Jolla, CA 92093 USA.

NATURE CELL BIOLOGY, 2023; 25 (2):

Abstract

Wu et al. identify a mechanistic role for LPAR4 in promoting a fibronectin-rich extracellular matrix via AKT, CREB and integrins, thereby generating a......

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