High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia

Ghia, EM; Rassenti, LZ; Choi, MY; Quijada-Alamo, M; Chu, E; Widhopf, GF; Kipps, TJ

Kipps, TJ (通讯作者)，Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.;Kipps, TJ (通讯作者)，Univ Calif San Diego, Ctr Novel Therapeut, La Jolla, CA 92037 USA.;Kipps, TJ (通讯作者)，Univ Calif San Diego, Dept Med, Div Hematol Oncol, La Jolla, CA 92093 USA.;Kipps, TJ (通讯作者)，Univ Calif San Diego, CIRM Alpha Stem Cell Clin, La Jolla, CA 92037 USA.;Kipps, TJ (通讯作者)，Sanford Stem Cell Clin Ctr, La Jolla, CA 92037 USA.

LEUKEMIA, 2022; 36 (6): 1609

Abstract

Although the BH3-mimetic venetoclax is highly cytotoxic for chronic lymphocytic leukemia (CLL) cells, some patients with CLL fail to clear minimal res......

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