Biocatalytic cascade process of islatravir: Analytical and regulatory control strategy of minor enantiomer

Chen, Y; Jo, J; Hernandez, E; Wang, HT; Bernardoni, F

Chen, Y; Jo, J (通讯作者)，Merck & Co Inc, Inc, Analyt Res & Dev, MRL, Rahway, NJ 07065 USA.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 234 ():

Abstract

Commercial process of islatravir (MK-8591, EFdA) utilizes biocatalytic cascade reactions to construct the ribose moiety of the molecule which bears th......

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