Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Jin, X; Merrett, J; Tong, S; Flower, B; Xie, JL; Yu, RL; Tian, SY; Gao, L; Zhao, JJ; Wang, XM; Jiang, T; Proud, CG

Jiang, T (reprint author), Ocean Univ China, Sch Med & Pharm, Qingdao, Peoples R China.; Jiang, T (reprint author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China.; Proud, CG (reprint author), South Australian

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019; 162 (): 735

Abstract

The mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate eukaryotic initiation factor 4E (eIF4E) and play import......

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