Inferring the shape of global epistasis

Otwinowski, J; McCandlish, DM; Plotkin, JB

Otwinowski, J (reprint author), Univ Penn, Biol Dept, Philadelphia, PA 19104 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (32): E7550

Abstract

Genotype-phenotype relationships are notoriously complicated. Idiosyncratic interactions between specific combinations of mutations occur and are diff......

Full Text Link