Discovery of a Potent and Selective Covalent p300/CBP Inhibitor

Mastracchio, A; Lai, CQ; Digiammarino, E; Ready, DB; Lasko, LM; Bromberg, KD; McClellan, WJ; Montgomery, D; Manaves, V; Shaw, B; Algire, M; Patterson, MJ; Sun, CC; Rosenberg, S; Lai, A; Michaelides, MR

Mastracchio, A (corresponding author), AbbVie Inc, N Chicago, IL 60064 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2021; 12 (5): 726

Abstract

Aberrant gene activation driven by the histone acetyltransferases p300 and CREB binding protein (CBP) has been linked to several diseases, including c......

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