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Click-based amplification: designed to facilitate various target labelling modes with ultralow background amplification

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (3)

We here describe a fluorescent signal amplification method termed "Click-based amplification" that can be well integrated with various click-labelling......

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (4)

Stapled peptides are promising protein-protein interaction (PPI) inhibitors that can increase the binding potency. Different from small-molecule inhib......

Outstanding Reviewers for RSC Chemical Biology in 2020

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (3)

We would like to take this opportunity to highlight the Outstanding Reviewers for RSC Chemical Biology in 2020, as selected by the editorial team for ......

Advances in single-cell multi-omics profiling

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (2)

Single-cell profiling methods are developed to dissect heterogeneity of cell populations. Recently, multiple enzymatic or chemical treatments have bee......

Quantification and mapping of DNA modifications

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (4)

Apart from the four canonical nucleobases, DNA molecules carry a number of natural modifications. Substantial evidence shows that DNA modifications ca......

Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2-nucleosome association

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (4)

Lysine succinylation (Ksucc) is a novel posttranslational modification that frequently occurs on chromatin proteins including histones and non-histone......

One-pot fluorescent assay for sensitive detection of APOBEC3A activity

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (4)

We reported a one-pot fluorescence-based assay to quantitively detect A3A activity combined with cytosine deamination and uracil excision. After deami......

Biological functions of supramolecular assemblies of small molecules in the cellular environment

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (2)

Like biomacromolecules, certain small molecules (e.g., aggregators) are able to self-assemble in the aqueous phase to form nanoscale aggregates. Thoug......

Recent development of near-infrared photoacoustic probes based on small-molecule organic dye

期刊: RSC CHEMICAL BIOLOGY, ; ()

Photoacoustic imaging (PAI), which integrates the higher spatial resolution of optical imaging and the deeper penetration depth of ultrasound imaging,......

A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (1)

Programmed cell death protein 1 (PD-1) is a crucial anticancer target, but the relatively low response rate and acquired resistance to existing antibo......

Biosynthesis of alkyne-containing natural products

期刊: RSC CHEMICAL BIOLOGY, 2021; 2 (1)

Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetyleni......

SIMULTANEOUS LAPAROSCOPIC BILATERAL NEPHROURETERECTOMY, CADAVERIC KIDNEY ALLOTRANSPLANTATION AND PERFORMANCE OF VESICOSTOMY IN A PATIENT WITH NEUROGENIC BLADDER

期刊: VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV, 2020; 22 (1)

We present a case of simultaneous laparoscopic bilateral nephroureterectomy, cadaveric kidney allotransplantation and performance of vesicostomy. This......

From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma

期刊: RSC CHEMICAL BIOLOGY, 2022; 3 (10)

Nucleic acids have been extensively modified in different moieties to expand the scope of genetic materials in the past few decades. While the develop......

Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

期刊: RSC CHEMICAL BIOLOGY, 2022; 3 (4)

We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, stru......

Protein scaffolds: antibody alternatives for cancer diagnosis and therapy

期刊: RSC CHEMICAL BIOLOGY, 2022; 3 (7)

Although antibodies are well developed and widely used in cancer therapy and diagnostic fields, some defects remain, such as poor tissue penetration, ......

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