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Pharmacological properties of baicalin on liver diseases: a narrative review

期刊: PHARMACOLOGICAL REPORTS, ; ()

Baicalin is the main active component of Scutellaria baicalensis, widely used in traditional Chinese medicine thanks to its various pharmacological ef......

Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease

期刊: PHARMACOLOGICAL REPORTS, ; ()

Inflammatory bowel disease (IBD) is an autoimmune disease mediated by immune disorder and termed as one of the most refractory diseases by the Word He......

Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis

期刊: PHARMACOLOGICAL REPORTS, 2021; 73 (2)

Rationale Recently, the effects of ketamine on the circadian rhythm have suggested that ketamine's rapid antidepressant effects are associated with an......

Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (5)

Background The use of nonsteroidal anti-inflammatory drugs (NSAIDs) can promote lower gastrointestinal detrimental effects. Proteinase-activated recep......

Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (4)

Background Prostate cancer (PCa) is the most common malignancy in men and in the absence of any effective treatments available. Methods For the develo......

Evidence of the involvement of spinal alpha B-crystallin in the maintenance of bone cancer pain in rats

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (1)

Background: alpha B-crystallin (CRYAB) is a small heat shock protein that is able to inhibit neuroinflammatory responses under various pathological co......

Cleistanthin A inhibits the invasion of MDA-MB-231 human breast cancer cells: involvement of the beta-catenin pathway

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (1)

Background: Cleistanthin A (CleA), a natural diphyllin glycoside, has been shown to suppress the invasion of cancer cells, but the underlying mechanis......

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (1)

Background The current strategies for prevention and treatment of insulin resistance and type 2 diabetes are not fully effective and frequently accomp......

A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (4)

Background 2,4 ',5 '-Trihydroxyl-5,2 '-dibromo diphenylmethanone (LM49), a novel active halophenol derivative synthesized by our group from marine pla......

Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (4)

Background Neuroinflammation plays a dominant role in the progression of postoperative cognitive dysfunction (POCD). This study was carried out to exp......

Alpinumisoflavone suppresses hepatocellular carcinoma cell growth and metastasis via NLRP3 inflammasome-mediated pyroptosis

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (5)

Aim This research aims to explore the effect of alpinumisoflavone (AIF) as an anti-cancer drug for the treatment of patients with hepatocellular carci......

Atorvastatin alleviates left ventricular remodeling in isoproterenol-induced chronic heart failure in rats by regulating the RhoA/Rho kinase signaling pathway

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (4)

Background Chronic heart failure (CHF) is characterized by left ventricular dysfunction and altered autonomic control of cardiac function. This study ......

Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (5)

Background Telomerase plays an essential role in cancer cell proliferation. In this study, we investigated inhibition mechanism of aloe emodin (AE) on......

Propofol affects the growth and metastasis of pancreatic cancer via ADAM8

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (2)

Background Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate ......

Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways

期刊: PHARMACOLOGICAL REPORTS, 2020; 72 (2)

Background Tanshinone IIA (Tan IIA) and andrographolide (Andro) are natural compounds that are reported to exhibit anticancer activities against vario......

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