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HOXA13 promotes gastric cancer progression partially via the FN1-mediated FAK/Src axis

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Background Gastric cancer (GC) is one of the most common cancers causing a poor prognosis worldwide. HOXA13, as a member of the homeobox (HOX) family,......

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in t......

Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Background Patients receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor T cell (CAR T-cell) therapy are immunocompro......

CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Objective Circular RNAs (circRNAs) play a critical role in the modulation of tumor metabolism. However, the expression patterns and metabolic function......

Disease-free survival landmark analysis: a potential critical endpoint in triple-negative breast cancer

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Taxanes plus carboplatin (TP) regimen may be an acceptable alternative adjuvant chemotherapy strategy in patients with triple-negative breast cancer (......

p53 amyloid aggregation in cancer: function, mechanism, and therapy

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has been proposed in recent years. p53, the most well-known tum......

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of ca......

Immune related biomarkers for cancer metastasis to the brain

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Brain metastasis accounts for a large number of cancer-related deaths. The host immune system, involved at each step of the metastatic cascade, plays ......

DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored ......

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stage......

CD7-directed CAR T-cell therapy: a potential immunotherapy strategy for relapsed/refractory acute myeloid leukemia

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Relapsed/refractory acute myeloid leukemia (AML) patients generally have a dismal prognosis and the treatment remains challenging. Due to the expressi......

RHO GTPase family in hepatocellular carcinoma

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functio......

Targeting metabolic reprogramming in chronic lymphocytic leukemia

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of cancer, is considered as a promising therapeutic target against tu......

Role of m6A writers, erasers and readers in cancer

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have su......

Rituximab, lenalidomide and BTK inhibitor as frontline treatment for elderly or unfit patients with diffuse large B-cell lymphoma: a real-world analysis of single center

期刊: EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022; 11 (1)

The combination of rituximab, lenalidomide, and Bruton's tyrosine kinase inhibitor (BTKi) ibrutinib, followed by chemotherapy, has shown high efficacy......

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