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Characterization of fragment sizes, copy number aberrations and 4-mer end motifs in cell-free DNA of hepatocellular carcinoma for enhanced liquid biopsy-based cancer detection

期刊: MOLECULAR ONCOLOGY, 2021; 15 (9)

Circulating cell-free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA mo......

Tumour-derived substrate-adherent cells promote neuroblastoma survival through secreted trophic factors

期刊: MOLECULAR ONCOLOGY, 2021; 15 (8)

Neuroblastoma (NB) is the most common extracranial solid tumour in children. NB is highly heterogeneous and is comprised of a mixture of neuroblastic ......

Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer

期刊: MOLECULAR ONCOLOGY, 2021; 15 (9)

Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN-negative breast cancer (BC) patients but it is prone to false-nega......

The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms

期刊: MOLECULAR ONCOLOGY, 2021; 15 (7)

Metastatic neuroendocrine prostate cancer (NEPC) is a highly aggressive disease, whose incidence is rising. Long noncoding RNAs (lncRNAs) represent a ......

Phosphorylation of the androgen receptor at Ser81 is co-sustained by CDK1 and CDK9 and leads to AR-mediated transactivation in prostate cancer

期刊: MOLECULAR ONCOLOGY, 2021; 15 (7)

Androgen receptor (AR) is the principal molecule in prostate cancer (PCa) etiology and therapy. AR re-activation still remains a major challenge durin......

Adoptive transfer of immature myeloid cells lacking NF-kappa B p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma

期刊: MOLECULAR ONCOLOGY, 2021; 15 (7)

High-risk neuroblastomas harbor abundant myeloid cells that suppress antitumor immunity and support tumor growth. Macrophages lacking the inhibitory N......

A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558

期刊: MOLECULAR ONCOLOGY, ; ()

Circular RNAs (circRNAs) are single-stranded RNAs which form a covalently closed continuous loop. Although originally shown to be non-protein-coding, ......

Enhancing cancer-associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis

期刊: MOLECULAR ONCOLOGY, ; ()

Most cancer-related deaths result from the progressive growth of metastases. Patients with peritoneal metastatic (PM) colorectal cancer have reduced o......

Irradiation-induced polyploid giant cancer cells are involved in tumor cell repopulation via neosis

期刊: MOLECULAR ONCOLOGY, ; ()

Tumor repopulation occurs when residual tumor cells surviving therapies tenaciously proliferate and re-establish the tumor. The cellular and molecular......

Small extracellular vesicles deliver TGF-beta 1 and promote adriamycin resistance in breast cancer cells

期刊: MOLECULAR ONCOLOGY, ; ()

Chemotherapeutic resistance is a major obstacle in the control of advanced breast cancer (BCa). We have previously shown that small extracellular vesi......

The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma

期刊: MOLECULAR ONCOLOGY, ; ()

Esophageal squamous cell carcinoma (ESCC) is one of the most refractory malignancies worldwide. Mitogen-activated protein kinase 3 (MAP2K3) has a cont......

FOXM1D potentiates PKM2-mediated tumor glycolysis and angiogenesis

期刊: MOLECULAR ONCOLOGY, ; ()

Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been repor......

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis

期刊: MOLECULAR ONCOLOGY, ; ()

Despite recent progress in non-small-cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of treatment resistance or tox......

Long non-coding RNA SNHG1 stimulates ovarian cancer progression by modulating expression of miR-454 and ZEB1

期刊: MOLECULAR ONCOLOGY, ; ()

Ovarian cancer (OC) is highly prevalent and is associated with high mortality rates due to metastasis and relapse. In this study, we assessed the role......

LncRNA-ZXF1 regulates P21 expression in endometrioid endometrial carcinoma by managing ubiquitination-mediated degradation and miR-378a-3p/PCDHA3 axis

期刊: MOLECULAR ONCOLOGY, ; ()

Long noncoding RNAs (lncRNAs) have a profound effect on biological processes in various malignancies. However, few studies have investigated their fun......

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